KOR Agonist 2 (Compound 23p) is a potent agonist of the κ-opioid receptor (KOR) with a Ki value of 1.9 nM. It demonstrates significant analgesic properties in mouse models, exhibiting an effective dose (ED50) of 1.30 mg/kg. Additionally, KOR Agonist 2 shows a high clearance rate when administered intravenously at 2 mg/kg and undergoes substantial metabolism in liver microsomes, making it a valuable tool for research in pain management and opioid receptor pharmacology.
KOR Agonist 2 (Compound 23p) is a potent agonist of the κ-opioid receptor (KOR) with a Ki value of 1.9 nM. It demonstrates significant analgesic properties in mouse models, exhibiting an effective dose (ED50) of 1.30 mg/kg. Additionally, KOR Agonist 2 shows a high clearance rate when administered intravenously at 2 mg/kg and undergoes substantial metabolism in liver microsomes, making it a valuable tool for research in pain management and opioid receptor pharmacology.
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