KRC-00715 is a potent oral inhibitor of c-Met with an IC50 of 9.0 nM, exhibiting high selectivity for gastric cancer cells. This compound effectively induces G1/S phase arrest in c-Met-overexpressing cell lines, resulting in diminished downstream signaling through Akt and Erk pathways as well as reduced c-Met activity. In the gastric cancer cell line Hs746, KRC-00715 demonstrates an IC50 of 39 nM and shows significant efficacy in reducing tumor size in Hs746T xenograft mouse models, highlighting its potential application in cancer research and therapeutics.
KRC-00715 is a potent oral inhibitor of c-Met with an IC50 of 9.0 nM, exhibiting high selectivity for gastric cancer cells. This compound effectively induces G1/S phase arrest in c-Met-overexpressing cell lines, resulting in diminished downstream signaling through Akt and Erk pathways as well as reduced c-Met activity. In the gastric cancer cell line Hs746, KRC-00715 demonstrates an IC50 of 39 nM and shows significant efficacy in reducing tumor size in Hs746T xenograft mouse models, highlighting its potential application in cancer research and therapeutics.
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