KST012174 hydrochloride is a selective inhibitor of the HIF-1α-p300/CBP interaction, demonstrating an IC50 of 107 μM. It effectively disrupts the binding of HIF-1α to the p300 protein at concentrations of 100 μM without altering HIF-1α protein stability. By targeting the C-terminal transactivation domain of HIF-1α and the CH1 domain of p300, KST012174 hydrochloride inhibits HIF-1α-mediated transcriptional activation, leading to decreased VEGF mRNA expression and suppression of tumor angiogenesis. This reagent is valuable for research into cancer biology and hypoxia-related pathways.
KST012174 hydrochloride is a selective inhibitor of the HIF-1α-p300/CBP interaction, demonstrating an IC50 of 107 μM. It effectively disrupts the binding of HIF-1α to the p300 protein at concentrations of 100 μM without altering HIF-1α protein stability. By targeting the C-terminal transactivation domain of HIF-1α and the CH1 domain of p300, KST012174 hydrochloride inhibits HIF-1α-mediated transcriptional activation, leading to decreased VEGF mRNA expression and suppression of tumor angiogenesis. This reagent is valuable for research into cancer biology and hypoxia-related pathways.
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