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Biological Activity
KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively).
Targets
| mTORC1 (Cell-free assay) | mTORC2 (Cell-free assay) | |||
| ~10 nM | ~10 nM |
| In vitro (25°C) | DMSO | 16 mg/mL (34.36 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.48 mL | 107.41 mL | 214.82 mL |
| 0.5 mM | 4.3 mL | 21.48 mL | 42.96 mL |
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10505 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 938440-64-3 |
| Formula | C25H31N5O4 |
| M. Wt | 465.5 |
| Purity | >98% |
| Synonyms | KU0063794 |
| SMILES | C[[email protected]@H]1CN(C[[email protected]@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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