Kushenol E is a flavonoid derived from Sophora flavescens and acts as a non-competitive inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with an IC50 of 7.7 µM and a Ki of 9.5 µM. This compound exhibits notable anti-tumor activity, making it relevant for research applications in cancer biology and immunotherapy. Its mechanism of action provides potential insights into immune modulation within the tumor microenvironment.
Kushenol E is a flavonoid derived from Sophora flavescens and acts as a non-competitive inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with an IC50 of 7.7 µM and a Ki of 9.5 µM. This compound exhibits notable anti-tumor activity, making it relevant for research applications in cancer biology and immunotherapy. Its mechanism of action provides potential insights into immune modulation within the tumor microenvironment.
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