Kv7.2/Kv7.3 activator-3 is a potent activator targeting the Kv7.2 and Kv7.3 potassium channels, as well as the translocator protein (TSPO). It demonstrates biological activities by activating Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and showing binding affinity to TSPO with Ki values of 0.07 μM and 4.60 μM in rat and human cells, respectively. This compound has been shown to prevent motor neuron degeneration associated with ALS/FTD, stimulate axonal growth in dorsal root ganglia, and exhibit anti-epileptic effects. Additionally, it alleviates pain hypersensitivity in diabetic neuropathy and promotes neuronal survival after cervical injury in preclinical models.
Kv7.2/Kv7.3 activator-3 is a potent activator targeting the Kv7.2 and Kv7.3 potassium channels, as well as the translocator protein (TSPO). It demonstrates biological activities by activating Kv7.2/Kv7.3, Kv7.4, and Kv7.5 with EC50 values of 0.37, 2.06, and 0.75 μM, respectively, and showing binding affinity to TSPO with Ki values of 0.07 μM and 4.60 μM in rat and human cells, respectively. This compound has been shown to prevent motor neuron degeneration associated with ALS/FTD, stimulate axonal growth in dorsal root ganglia, and exhibit anti-epileptic effects. Additionally, it alleviates pain hypersensitivity in diabetic neuropathy and promotes neuronal survival after cervical injury in preclinical models.
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