L-364,373 is a selective activator of the voltage-gated Kv7.1 (KCNQ1) channels. It enhances the Iks (slow delayed rectifier potassium current) and significantly shortens action potential duration in guinea pig cardiac myocytes, while also suppressing early afterdepolarizations in rabbit ventricular myocytes. This compound is valuable for research on cardiac electrophysiology and the mechanisms underlying cardiac arrhythmias.
L-364,373 is a selective activator of the voltage-gated Kv7.1 (KCNQ1) channels. It enhances the Iks (slow delayed rectifier potassium current) and significantly shortens action potential duration in guinea pig cardiac myocytes, while also suppressing early afterdepolarizations in rabbit ventricular myocytes. This compound is valuable for research on cardiac electrophysiology and the mechanisms underlying cardiac arrhythmias.
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