L-735821 is a potassium channel blocker specifically targeting the KCNQ1 channel. It exhibits potent antagonistic activity with an EC50 of 0.08 μM, effectively influencing current-voltage relationships of IKs and IKr in rabbit ventricular myocytes. Additionally, L-735821 completely inhibits IKs in isolated human ventricular myocytes at a concentration of 100 nmol/L, demonstrating its efficacy in modulating cardiac ion currents. This compound is well-suited for research focused on cardiac electrophysiology and the role of potassium channels in cardiac function.
L-735821 is a potassium channel blocker specifically targeting the KCNQ1 channel. It exhibits potent antagonistic activity with an EC50 of 0.08 μM, effectively influencing current-voltage relationships of IKs and IKr in rabbit ventricular myocytes. Additionally, L-735821 completely inhibits IKs in isolated human ventricular myocytes at a concentration of 100 nmol/L, demonstrating its efficacy in modulating cardiac ion currents. This compound is well-suited for research focused on cardiac electrophysiology and the role of potassium channels in cardiac function.
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