L-764406 is a high-affinity non-thiazolidinedione ligand for the peroxisome proliferator-activated receptor gamma (PPARγ). Demonstrating partial agonist activity, L-764406 activates the expression of adipocyte-specific genes, such as aP2, in both chimeric receptors containing the PPARγ ligand-binding domain and in 3T3-L1 cell models. Notably, L-764406 does not exhibit activity with PPARα or PPARδ, making it a selective tool for studying PPARγ-related pathways and their implications in metabolic research.
L-764406 is a high-affinity non-thiazolidinedione ligand for the peroxisome proliferator-activated receptor gamma (PPARγ). Demonstrating partial agonist activity, L-764406 activates the expression of adipocyte-specific genes, such as aP2, in both chimeric receptors containing the PPARγ ligand-binding domain and in 3T3-L1 cell models. Notably, L-764406 does not exhibit activity with PPARα or PPARδ, making it a selective tool for studying PPARγ-related pathways and their implications in metabolic research.
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