L-97-1

Catalog No.: A58042
A1AR Antagonist
L-97-1 is a selective antagonist of the A1 adenosine receptor (A1AR). This water-soluble small molecule exhibits high affinity for human A1AR, effectively blocking receptor activation. By competitively inhibiting A1AR, L-97-1 alleviates adenosine-induced bronchoconstriction and inflammation, making it a valuable tool in asthma research and the study of airway hyperreactivity. Its action can contribute to a better understanding of therapeutic approaches for respiratory conditions associated with adenosine signaling.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionL-97-1 is a selective antagonist of the A1 adenosine receptor (A1AR). This water-soluble small molecule exhibits high affinity for human A1AR, effectively blocking receptor activation. By competitively inhibiting A1AR, L-97-1 alleviates adenosine-induced bronchoconstriction and inflammation, making it a valuable tool in asthma research and the study of airway hyperreactivity. Its action can contribute to a better understanding of therapeutic approaches for respiratory conditions associated with adenosine signaling.
Product Information
Catalog NumA58042
FormulaC29H38N6O3
Molecular Weight518.65
CAS Number770703-20-3
SMILESO=C(N1CCC)N(CCC2=CC=C(N)C=C2)C3=C(N(CCN(CC)CCO)C(CC4=CC=CC=C4)=N3)C1=O
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