L-Azidonorleucine hydrochloride serves as an unnatural amino acid and a methionine surrogate, useful for labeling proteins in mammalian cells. It enables the identification of a broad range of methionyl-tRNA synthetase mutants. Additionally, this compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, including those with DBCO or BCN groups. Its unique properties make it a valuable tool for applications in click chemistry and protein labeling studies.
L-Azidonorleucine hydrochloride serves as an unnatural amino acid and a methionine surrogate, useful for labeling proteins in mammalian cells. It enables the identification of a broad range of methionyl-tRNA synthetase mutants. Additionally, this compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, including those with DBCO or BCN groups. Its unique properties make it a valuable tool for applications in click chemistry and protein labeling studies.
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