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LacNAc-VC-PAB-MMAE

Catalog No.: A41418
Drug-Linker Conjugate for ADC
LacNAc-VC-PAB-MMAE is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound is specifically engineered for attachment at the N-glycosylation site of Trastuzumab, utilizing WT Endo-S2 for assembly. LacNAc-VC-PAB-MMAE facilitates targeted delivery of cytotoxic agents, enhancing therapeutic efficacy in cancer treatment applications. Its innovative design supports research in ADC optimization and development for improved specificity and reduced systemic toxicity.
LacNAc-VC-PAB-MMAE 2823367-88-8 Drug-Linker Conjugate for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLacNAc-VC-PAB-MMAE is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound is specifically engineered for attachment at the N-glycosylation site of Trastuzumab, utilizing WT Endo-S2 for assembly. LacNAc-VC-PAB-MMAE facilitates targeted delivery of cytotoxic agents, enhancing therapeutic efficacy in cancer treatment applications. Its innovative design supports research in ADC optimization and development for improved specificity and reduced systemic toxicity.
Product Information
Catalog NumA41418
FormulaC74H116N12O23
Molecular Weight1541.78
CAS Number2823367-88-8
SMILESO=C(CO/N=C/[C@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O)O[C@H]2[C@@H]([C@H]3N=C(O[C@H]3O[C@@H]2CO)C)O)N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(COC(N(C)[C@H](C(N[C@H](C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N5CCC[C@H]5[C@@H]([C@H](C(N[C@@H]([C@@H](O)C6=CC=CC=C6)C)=O)C)OC)=O)=O)C(C)C)=O)C(C)C)=O)C=C4)=O)=O)C(C)C
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC