LC-MB12

Name: LC-MB12
Brand: Adooq Bioscience
SKU: A24501
Rating: 5 (288 reviews)

Catalog No.: A24501

PROTAC FGFR2 Degrader

LC-MB12 is an orally active PROTAC compound that targets FGFR2 degradation, with a DC₅₀ of 11.8 nM. It consists of the FGFR2 inhibitor BGJ398, a PROTAC linker, and a cereblon (CRBN) ligand. LC-MB12 effectively inhibits FGFR2 signaling in gastric cancer cells and exhibits antitumor activity.

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LC-MB12 2828438-38-4 PROTAC FGFR2 Degrader

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Grouped product items
Size	Price	Stock
5mg	$315.00	In stock
10mg	$543.00	In stock
50mg	$1,610.00	In stock
100mg	$3,150.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	LC-MB12 is an orally active PROTAC compound that targets FGFR2 degradation, with a DC₅₀ of 11.8 nM. It consists of the FGFR2 inhibitor BGJ398, a PROTAC linker, and a cereblon (CRBN) ligand. LC-MB12 effectively inhibits FGFR2 signaling in gastric cancer cells and exhibits antitumor activity.

Product Information

Catalog Num	A24501
Formula	C43H44Cl2N10O8
Molecular Weight	899.78
CAS Number	2828438-38-4
SMILES	O=C(N(C)C1=CC(NC2=CC=C(N3CCN(CC3)C(C4CCN(CC4)C5=CC=C6C(N(C7C(NC(CC7)=O)=O)C(C6=C5)=O)=O)=O)C=C2)=NC=N1)NC8=C(Cl)C(OC)=CC(OC)=C8Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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