LCL-PEG3-N3 hydrochloride is a decoy oligonucleotide ligand targeting E3 ligases, facilitating the development of chimeric molecules such as LCL-ER(dec) for the degradation of estrogen receptors. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with reagents containing DBCO or BCN groups, making it a versatile tool for click chemistry applications in chemical biology research.
LCL-PEG3-N3 hydrochloride is a decoy oligonucleotide ligand targeting E3 ligases, facilitating the development of chimeric molecules such as LCL-ER(dec) for the degradation of estrogen receptors. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with reagents containing DBCO or BCN groups, making it a versatile tool for click chemistry applications in chemical biology research.
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