LCL-PEG3-N3 is a decoy oligonucleotide ligand targeting E3 ligases, facilitating the development of chimeric molecules such as LCL-ER(dec) for the degradation of estrogen receptors. As a versatile click chemistry reagent, it features an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, LCL-PEG3-N3 can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with DBCO or BCN-modified entities. This compound is valuable in chemical biology applications and protein degradation studies.
LCL-PEG3-N3 is a decoy oligonucleotide ligand targeting E3 ligases, facilitating the development of chimeric molecules such as LCL-ER(dec) for the degradation of estrogen receptors. As a versatile click chemistry reagent, it features an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, LCL-PEG3-N3 can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with DBCO or BCN-modified entities. This compound is valuable in chemical biology applications and protein degradation studies.
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