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LDE225 (NVP-LDE225, Sonidegib)


Smo Antagonist

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Catalog No. A10520

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LDE225 5mg A10520-5

Regular Price: $50.00

Special Price: $45.00

LDE225 10mg A10520-10

Regular Price: $70.00

Special Price: $63.00

LDE225 50mg A10520-50

Regular Price: $150.00

Special Price: $135.00

LDE225 100mg A10520-100

Regular Price: $250.00

Special Price: $225.00

LDE225 (NVP-LDE225) 10mM * 1mL in DMSO A10520-10mM-D

Regular Price: $50.00

Special Price: $45.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).

LDE225 (NVP-LDE225, Sonidegib)

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Chemical Information

Catalog Num A10520
Actions Antagonist
M. Wt 485.5
Formula C26H26F3N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 956697-53-3
Synonyms LDE-225
SMILES C[[email protected]@H]1CN(C[[email protected]@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F

Biological Activity

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
Smo (mouse) (Cell-free assay) Smo (human) (Cell-free assay)
1.3 nM2.5 nM


Solubility (25°C) * In vitro DMSO 97 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 97 mg/mL (199.79 mM)
In vivo 0.5% CMC 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.6 mL 102.99 mL 205.97mL
0.5 mM 4.12 mL 20.6 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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