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LDE225 (NVP-LDE225, Sonidegib)

Catalog No.: A10520

Smo Antagonist

LDE225 (NVP-LDE225, Sonidegib)

LDE225 (NVP-LDE225, Sonidegib) Chemical Structure

CAS NO. 956697-53-3

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$70.00
50 mg
$150.00
100 mg
$250.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

Biological Activity

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
Targets
Smo (mouse) (Cell-free assay) Smo (human) (Cell-free assay)
1.3 nM2.5 nM
In vitro (25°C) DMSO 82 mg/mL (168.89 mM)
Water Insoluble
Ethanol Warmed: 82 mg/mL (168.89 mM)
In vivo 2% DMSO+corn oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.6 mL 102.99 mL 205.97 mL
0.5 mM 4.12 mL 20.6 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10520
Actions Antagonist
CAS No. 956697-53-3
Formula C26H26F3N3O3
M. Wt 485.5
Purity >98%
Synonyms LDE-225
SMILES C[[email protected]@H]1CN(C[[email protected]@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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