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- Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
Biological Activity
LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).
Targets
| Smo (mouse) (Cell-free assay) | Smo (human) (Cell-free assay) | |||
| 1.3 nM | 2.5 nM |
| In vitro (25°C) | DMSO | 82 mg/mL (168.89 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 82 mg/mL (168.89 mM) | ||
| In vivo | 2% DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.6 mL | 102.99 mL | 205.97 mL |
| 0.5 mM | 4.12 mL | 20.6 mL | 41.19 mL |
| 1 mM | 2.06 mL | 10.3 mL | 20.6 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10520 |
|---|---|
| Actions | Antagonist |
| CAS No. | 956697-53-3 |
| Formula | C26H26F3N3O3 |
| M. Wt | 485.5 |
| Purity | >98% |
| Synonyms | LDE-225 |
| SMILES | C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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