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LE01

Catalog No.: A41553
Drug-Linker Conjugates for ADC
LE01 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It incorporates a linker suitable for ADC synthesis and the DNA topoisomerase I inhibitor DXd, facilitating targeted therapy. LE01 is particularly useful in generating HER2-targeting ADCs, enabling selective delivery of cytotoxic agents to HER2-expressing tumors for enhanced therapeutic efficacy.
LE01 2718125-83-6 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLE01 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It incorporates a linker suitable for ADC synthesis and the DNA topoisomerase I inhibitor DXd, facilitating targeted therapy. LE01 is particularly useful in generating HER2-targeting ADCs, enabling selective delivery of cytotoxic agents to HER2-expressing tumors for enhanced therapeutic efficacy.
Product Information
Catalog NumA41553
FormulaC55H61FN10O14
Molecular Weight1105.13
CAS Number2718125-83-6
SMILESO=C(C=C1)N(CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCCN(C)C(OCC(N[C@H]3CCC4=C5C3=C6C(C(N7C6)=CC([C@@](O)(CC)C(OC8)=O)=C8C7=O)=NC5=CC(F)=C4C)=O)=O)=O)=O)=O)=O)=O)C1=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC