LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) designed to link AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a C3 alkyl linker. This compound demonstrates notable stabilization of WEE1 in HEP3B hepatoma cancer cells, indicating its potential role in enhancing the therapeutic efficacy of WEE1 inhibition. LEB-03-144 is suitable for studies focused on cancer biology and drug discovery applications targeting WEE1-mediated signaling pathways.
LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) designed to link AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a C3 alkyl linker. This compound demonstrates notable stabilization of WEE1 in HEP3B hepatoma cancer cells, indicating its potential role in enhancing the therapeutic efficacy of WEE1 inhibition. LEB-03-144 is suitable for studies focused on cancer biology and drug discovery applications targeting WEE1-mediated signaling pathways.
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