LEE011 (Ribociclib)

Name: LEE011 (Ribociclib)
Brand: Adooq Bioscience
SKU: A13549
Rating: 100 (268 reviews)

Catalog No.: A13549

CDK4/6 inhibitor

LEE011 (Ribociclib) Chemical Structure

CAS NO. 1211441-98-3

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
10 mg	$80.00
25 mg	$120.00
50 mg	$150.00
Custom Size	Get quote

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Biological Activity

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

Targets

CDK4 (Cell-free assay)	CDK6 (Cell-free assay)

Solubility *

In vitro	DMSO	7 mg/mL (16.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.06 mL	230.13 mL
0.5 mM	4.6 mL	23.01 mL	46.03 mL
1 mM	2.3 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13549
Actions	Inhibitor
CAS No.	1211441-98-3
Formula	C23H30N8O
M. Wt	434.54
Purity	>98%
Synonyms	LEE-011, LEE 011
SMILES	CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.