Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
Biological Activity
LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
Targets
CDK4 (Cell-free assay) | CDK6 (Cell-free assay) | |||
In vitro | DMSO | 7 mg/mL (16.1 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.01 mL | 115.06 mL | 230.13 mL |
0.5 mM | 4.6 mL | 23.01 mL | 46.03 mL |
1 mM | 2.3 mL | 11.51 mL | 23.01 mL |
5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A13549 |
---|---|
Actions | Inhibitor |
CAS No. | 1211441-98-3 |
Formula | C23H30N8O |
M. Wt | 434.54 |
Purity | >98% |
Synonyms | LEE-011, LEE 011 |
SMILES | CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Indirubin
Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 …
CGP60474
CGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK).
AG-024322
AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and a…
JNJ-7706621
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than C…
TG003
TG003 is a potent, specific, reversible, and ATP competitive inhibitor of Cdc2 like kinase(Clk).-
PD 0332991 HCl (Palbociclib)
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activit…
Kenpaullone
Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with …
NVP-LCQ195
NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
Keywords:buy LEE011 (Ribociclib) | LEE011 (Ribociclib) Supplier | purchase | cost | manufacturer | order | distributor | buy 1211441-98-3| 1211441-98-3 Supplier | purchase 1211441-98-3 | 1211441-98-3 cost | 1211441-98-3 manufacturer | order 1211441-98-3 | 1211441-98-3 distributor