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LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
Targets
| CDK4 (Cell-free assay) | CDK6 (Cell-free assay) | |||
| In vitro | DMSO | 7 mg/mL (16.1 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.01 mL | 115.06 mL | 230.13 mL |
| 0.5 mM | 4.6 mL | 23.01 mL | 46.03 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.01 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13549 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1211441-98-3 |
| Formula | C23H30N8O |
| M. Wt | 434.54 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | LEE-011, LEE 011 |
| SMILES | CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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