LEE011 (Ribociclib)

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
Grouped product items
Size Price Stock Qty
2mg
$30.00
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5mg
$50.00
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10mg
$70.00
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25mg
$90.00
In stock
50mg
$110.00
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100mg
$170.00
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500mg
$435.00
In stock
10mM * 1mL in DMSO
$55.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's LEE011 (Ribociclib) has been cited by 2 publications
  • Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591
  • Federico Antoniciello, .et al. , Front Mol Biosci, 2023, May 11;9:887564 PMID: 35647033
  • Biological Activity
    Discription LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A13549
    Formula C23H30N8O
    Molecular Weight 434.54
    CAS Number 1211441-98-3
    SMILES CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
    Synonyms LEE-011, LEE 011
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 7 mg/mL (16.1 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.01 mL 115.06 mL 230.13 mL
    0.5 mM 4.6 mL 23.01 mL 46.03 mL
    1 mM 2.3 mL 11.51 mL 23.01 mL
    5 mM 0.46 mL 2.3 mL 4.6 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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