Lenalidomide-5-bromopentanamide

Catalog No.: A80302
E3 Ligase Ligand-Linker Conjugate
Lenalidomide-5-bromopentanamide is an E3 ligase ligand-linker conjugate that combines the CRBN ligand Lenalidomide with a 5-bromopentanoyl linker. This compound is essential for the synthesis of PROTACs, which facilitate targeted protein degradation in cellular systems. Its application is pivotal in drug discovery and development, particularly in exploring the therapeutic potential of novel degraders in various diseases.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLenalidomide-5-bromopentanamide is an E3 ligase ligand-linker conjugate that combines the CRBN ligand Lenalidomide with a 5-bromopentanoyl linker. This compound is essential for the synthesis of PROTACs, which facilitate targeted protein degradation in cellular systems. Its application is pivotal in drug discovery and development, particularly in exploring the therapeutic potential of novel degraders in various diseases.
Product Information
Catalog NumA80302
FormulaC18H20BrN3O4
Molecular Weight422.27
CAS Number2545963-24-2
SMILESBrCCCCC(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)=O
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