Lenalidomide-C4-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that targets the Cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN for targeted protein degradation applications through PROTAC technology. In studies, Lenalidomide-C4-NH2 hydrochloride has demonstrated potent anti-proliferative effects, exhibiting IC50 values of 0.98 nM and 13.7 nM against RS4;11 and MOLM-13 acute leukemia cell lines, respectively. This makes it a valuable tool for research in cancer biology and therapeutic development.
Lenalidomide-C4-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that targets the Cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN for targeted protein degradation applications through PROTAC technology. In studies, Lenalidomide-C4-NH2 hydrochloride has demonstrated potent anti-proliferative effects, exhibiting IC50 values of 0.98 nM and 13.7 nM against RS4;11 and MOLM-13 acute leukemia cell lines, respectively. This makes it a valuable tool for research in cancer biology and therapeutic development.
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