Lenalidomide-COCH-PEG2-azido

Catalog No.: A80433

E3 Ligase Ligand-Linker Conjugate

Lenalidomide-COCH-PEG2-azido is an E3 ligase ligand-linker conjugate designed to target cereblon, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in synthesizing PROTAC AKR1C3 degrader-1, aiding researchers in studying protein turnover and degradation pathways. It is particularly useful in the investigation of cellular responses to E3 ligase modulation and the development of novel biotherapeutic approaches.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLenalidomide-COCH-PEG2-azido is an E3 ligase ligand-linker conjugate designed to target cereblon, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in synthesizing PROTAC AKR1C3 degrader-1, aiding researchers in studying protein turnover and degradation pathways. It is particularly useful in the investigation of cellular responses to E3 ligase modulation and the development of novel biotherapeutic approaches.
Product Information
Catalog NumA80433
FormulaC19H22N6O6
Molecular Weight430.41
CAS Number2380273-88-9
SMILES[N-]=[N+]=NCCOCCOCC(NC1=CC=CC2=C1CN(C3C(NC(CC3)=O)=O)C2=O)=O
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