Fig. 1 · Structure
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Lenalidomide-OH
Ligands For E3 Ligase
Lenalidomide-OH is a potent analog of the cereblon (CRBN) ligand Lenalidomide, designed to selectively engage E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN protein, essential for targeted protein degradation applications. Lenalidomide-OH can be coupled with various ligands via a linker to construct PROTACs, such as the BTK degrader SJF620, making it a valuable tool in studies of protein homeostasis and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1416990-08-3 |
| Applications | Ligands For E3 Ligase |
| Formula | C13H12N2O4 |
| Molecular Weight | 260.25 |
| SMILES | O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.