Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate featuring the Lenalidomide-based cereblon ligand. This compound facilitates the design of PROTACs, such as BRD4 Degrader-2, by promoting targeted protein degradation. Lenalidomide-PEG1-azide serves as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Suitable for applications in drug development and cellular biology research.
Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate featuring the Lenalidomide-based cereblon ligand. This compound facilitates the design of PROTACs, such as BRD4 Degrader-2, by promoting targeted protein degradation. Lenalidomide-PEG1-azide serves as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Suitable for applications in drug development and cellular biology research.
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