Lenalidomide-PEG3-iodine is an E3 ligase ligand-linker conjugate that combines a Lenalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG) linker. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs), including the potent BTK degrader SJF620, which demonstrates a DC50 of 7.9 nM. Lenalidomide-PEG3-iodine is valuable for research in targeted protein degradation and the development of innovative therapeutic strategies.
Lenalidomide-PEG3-iodine is an E3 ligase ligand-linker conjugate that combines a Lenalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG) linker. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs), including the potent BTK degrader SJF620, which demonstrates a DC50 of 7.9 nM. Lenalidomide-PEG3-iodine is valuable for research in targeted protein degradation and the development of innovative therapeutic strategies.
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