Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is an E3 ligase ligand-linker conjugate featuring a cereblon (CRBN) ligand. This compound facilitates the design of PROTACs, such as MD-224, enabling targeted protein degradation through the modulation of ubiquitin-proteasome pathways. Additionally, it serves as a click chemistry reagent, containing an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a versatile tool for chemical biology research.
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is an E3 ligase ligand-linker conjugate featuring a cereblon (CRBN) ligand. This compound facilitates the design of PROTACs, such as MD-224, enabling targeted protein degradation through the modulation of ubiquitin-proteasome pathways. Additionally, it serves as a click chemistry reagent, containing an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a versatile tool for chemical biology research.
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