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Biological Activity
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.12 mL | 115.59 mL | 231.18 mL |
| 0.5 mM | 4.62 mL | 23.12 mL | 46.24 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
*The above data is based on the productmolecular weight 432.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A20941 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1204975-42-7 |
| Formula | C25H32N6O |
| M. Wt | 432.56 |
| Purity | >98% |
| Synonyms | NVP-LEQ506, LEQ 506, LEQ-506 |
| SMILES | OC(C)(C)C1=NC=C(N2[[email protected]](C)CN(C3=NN=C(CC4=CC=CC=C4)C(C)=C3C)CC2)N=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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