Lesogaberan hydrochloride acts as a potent and selective agonist for the GABAB receptor, exhibiting an EC50 of 8.6 nM for human recombinant GABAB receptors. It demonstrates high affinity for the rat GABAB and GABAA receptors, with Kis values of 5.1 nM and 1.4 μM, respectively. This compound is known to inhibit transient lower esophageal sphincter relaxation, making it a valuable tool in research related to gastrointestinal motility and related disorders.
Lesogaberan hydrochloride acts as a potent and selective agonist for the GABAB receptor, exhibiting an EC50 of 8.6 nM for human recombinant GABAB receptors. It demonstrates high affinity for the rat GABAB and GABAA receptors, with Kis values of 5.1 nM and 1.4 μM, respectively. This compound is known to inhibit transient lower esophageal sphincter relaxation, making it a valuable tool in research related to gastrointestinal motility and related disorders.
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