Letrozole

Catalog No.: A10523

Aromatase inhibitor

Letrozole

Letrozole Chemical Structure

CAS NO. 112809-51-5

Letrozole is an Aromatase inhibitor. CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1–3 μg/kg p.o.)

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10 mg
$20.00
50 mg
$50.00
100 mg
$65.00
10mM * 1mL in DMSO
$65.00
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  • WEI LIU, .et al. Randomized controlled trial comparing letrozole with laparoscopic ovarian drilling in women with clomiphene citrate-resistant polycystic ovary syndrome, Exp Ther Med, 2015, Oct; 10(4): 1297-1302 PMID: 26622481

Biological Activity

Letrozole is an Aromatase inhibitor. CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1–3 μg/kg p.o.)
Targets
Aromatase (Cell-free assay)
0.07 nM-20 nM
In vitro (25°C) DMSO 50 mg/mL (175.25 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC Na 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.05 mL 175.25 mL 350.51 mL
0.5 mM 7.01 mL 35.05 mL 70.1 mL
1 mM 3.51 mL 17.53 mL 35.05 mL
5 mM 0.7 mL 3.51 mL 7.01 mL

*The above data is based on the productmolecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10523
Actions Inhibitor
CAS No. 112809-51-5
Formula C17H11N5
M. Wt 285.3
Purity >98%
Synonyms CGS 20267, Femara, Piroxicam
SMILES C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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