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$0.00 - WEI LIU, .et al. Randomized controlled trial comparing letrozole with laparoscopic ovarian drilling in women with clomiphene citrate-resistant polycystic ovary syndrome, Exp Ther Med, 2015, Oct; 10(4): 1297-1302 PMID: 26622481
Biological Activity
Letrozole is an Aromatase inhibitor. CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1–3 μg/kg p.o.)
Targets
| Aromatase (Cell-free assay) | ||||
| 0.07 nM-20 nM |
| In vitro (25°C) | DMSO | 57 mg/mL (199.78 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% CMC | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.05 mL | 175.25 mL | 350.51 mL |
| 0.5 mM | 7.01 mL | 35.05 mL | 70.1 mL |
| 1 mM | 3.51 mL | 17.53 mL | 35.05 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
*The above data is based on the productmolecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10523 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 285.3 |
| Formula | C17H11N5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 112809-51-5 |
| Synonyms | CGS 20267, Femara, Piroxicam |
| SMILES | C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3 |
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