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Leumorphin, human

Catalog No.: A62443
κ Opioid Receptor Agonist
Leumorphin, human is a potent κ opioid receptor agonist that demonstrates significant activity in modulating pain and stress responses. This compound specifically inhibits contractions in the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum, providing insights into gastrointestinal motility and receptor pharmacology. Its distinctive action makes Leumorphin, human a valuable reagent for research involving opioid receptor signaling and the effects of κ agonism in various biological contexts.
Leumorphin, human 88846-98-4 κ Opioid Receptor Agonist
Grouped product items
Size Price Stock Qty
5mg
$350.00
In stock
10mg
$650.00
In stock
50mg
$2,000.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLeumorphin, human is a potent κ opioid receptor agonist that demonstrates significant activity in modulating pain and stress responses. This compound specifically inhibits contractions in the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum, providing insights into gastrointestinal motility and receptor pharmacology. Its distinctive action makes Leumorphin, human a valuable reagent for research involving opioid receptor signaling and the effects of κ agonism in various biological contexts.
Product Information
Catalog NumA62443
FormulaC150H224N42O46
Molecular Weight3351.64
CAS Number88846-98-4
SequenceTyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr-Arg-Ser-Gln-Glu-Asp-Pro-Asn-Ala-Tyr-Ser-Gly-Glu-Leu-Phe-Asp-Ala
Sequence shorteningYGGFLRRQFKVVTRSQEDPNAYSGELFDA
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CNC(CNC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)=O)CCCCN)=O)[C@@H](C)C)=O)C(C)C)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(O)=O)(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=CC=C6)C(N[C@H](C(N[C@H](C(O)=O)C)=O)CC(O)=O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CO)=O)=O)C)=O)CC(N)=O)=O)CCC4
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GPCR/G Protein > Opioid Receptors