LGK-974

Catalog No.: A12816
PORCN inhibitor
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
Grouped product items
Size Price Stock Qty
1mg
$35.00
In stock
2mg
$50.00
In stock
5mg
$85.00
In stock
10mg
$145.00
In stock
25mg
$295.00
In stock
50mg
$545.00
In stock
100mg
$810.00
In stock
10mM * 1mL in DMSO
$90.00
In stock
Bulk Size
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's LGK-974 has been cited by 6 publications
  • Uxia Gurriaran-Rodriguez, .et al. , Sci Adv, 2024, Dec 13;10(50):eado5914 PMID: 39661666
  • Sho Tsukamoto, .et al. , Development, 2023, Aug 1;150(15):dev201734 PMID: 37539462
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • A-Ri Cho, .et al. , Sci Rep, 2022, Apr 29;12(1):7013 PMID: 35487932
  • Yang JM, .et al. , Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
  • E Lemieux, .et al. , Oncogene, 2015, Sep 17; 34(38): 4914-4927 PMID: 25500543
  • Biological Activity
    Discription LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A12816
    Formula C23H20N6O
    Molecular Weight 396.44
    CAS Number 1243244-14-5
    SMILES CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
    Synonyms LGK974, LGK 974
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 76 mg/mL (191.7 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+corn oil 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.22 mL 126.12 mL 252.24 mL
    0.5 mM 5.04 mL 25.22 mL 50.45 mL
    1 mM 2.52 mL 12.61 mL 25.22 mL
    5 mM 0.5 mL 2.52 mL 5.04 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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