LGK-974

Catalog No.: A12816
PORCN inhibitor
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
Grouped product items
Product Name Price Stock Qty
LGK-974 5mg
$90.00
In stock
LGK-974 10mg
$150.00
In stock
LGK-974 25mg
$300.00
In stock
LGK-974 50mg
$550.00
In stock
LGK-974 10mM * 1mL in DMSO
$186.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's LGK-974 has been cited by 3 publications
  • A-Ri Cho, .et al. , Sci Rep, 2022, Apr 29;12(1):7013 PMID: 35487932
  • Yang JM, .et al. , Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
  • E Lemieux, .et al. , Oncogene, 2015, Sep 17; 34(38): 4914-4927 PMID: 25500543
  • Biological Activity
    Discription LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
    Targets
    Target Value
    Product Information
    Catalog Num A12816
    Formula C23H20N6O
    Molecular Weight 396.44
    CAS Number 1243244-14-5
    SMILES CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
    Synonyms LGK974, LGK 974
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 76 mg/mL (191.7 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+corn oil 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 25.22 mL 126.12 mL 252.24 mL
    0.5 mM 5.04 mL 25.22 mL 50.45 mL
    1 mM 2.52 mL 12.61 mL 25.22 mL
    5 mM 0.5 mL 2.52 mL 5.04 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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