LI-633 is a selective and orally active positive allosteric modulator (PAM) of the GABAA receptor, exhibiting a Ki value of 21 nM. This compound effectively potentiates GABA-induced inward currents, with EC50 values ranging from 8 nM for the α5β2γ2 subtype to 128 nM for α3β2γ2. Additionally, LI-633 enhances muscimol-induced GABAergic currents in rat dorsal root ganglion neurons, displaying an EC50 of 70.4 nM. This reagent is valuable for investigating mechanisms of visceral pain.
LI-633 is a selective and orally active positive allosteric modulator (PAM) of the GABAA receptor, exhibiting a Ki value of 21 nM. This compound effectively potentiates GABA-induced inward currents, with EC50 values ranging from 8 nM for the α5β2γ2 subtype to 128 nM for α3β2γ2. Additionally, LI-633 enhances muscimol-induced GABAergic currents in rat dorsal root ganglion neurons, displaying an EC50 of 70.4 nM. This reagent is valuable for investigating mechanisms of visceral pain.
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