Lidocaine hydrochloride hydrate is a sodium channel blocker that selectively inhibits voltage-gated sodium channels, demonstrating use dependence. It has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression, which subsequently leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. Additionally, as an amide derivative, lidocaine hydrochloride hydrate has potential applications in the study of ventricular arrhythmias.
Lidocaine hydrochloride hydrate is a sodium channel blocker that selectively inhibits voltage-gated sodium channels, demonstrating use dependence. It has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression, which subsequently leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. Additionally, as an amide derivative, lidocaine hydrochloride hydrate has potential applications in the study of ventricular arrhythmias.
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