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Biological Activity
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.14 mL | 85.68 mL | 171.35 mL |
| 0.5 mM | 3.43 mL | 17.14 mL | 34.27 mL |
| 1 mM | 1.71 mL | 8.57 mL | 17.14 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.43 mL |
*The above data is based on the productmolecular weight 583.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13136 |
|---|---|
| Actions | Antagonist |
| CAS No. | 2024548-03-4 |
| Formula | C31H29N5O7 |
| M. Wt | 583.59 |
| Purity | >98% |
| SMILES | O=C(O)C(C=C1)=CC=C1N2N=CC3=C2C4=CC([N+]([O-])=O)=C(N5CCN(C(OCC6=CC=CC=C6)=O)CC5)C=C4OC3(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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