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LJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
Targets
| RSK2 | RSK1 | RSK3 | ||
| 4 nM | 6 nM | 13 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.15 mL | 135.73 mL | 271.46 mL |
| 0.5 mM | 5.43 mL | 27.15 mL | 54.29 mL |
| 1 mM | 2.71 mL | 13.57 mL | 27.15 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A14373 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 368.38 |
| Formula | C21H18F2N2O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1627709-94-7 |
| Synonyms | LJI 308, LJI-30 |
| SMILES | OC1=C(F)C=C(C2=C(C3=CC=C(N4CCOCC4)C=C3)C=CN=C2)C=C1F |
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