Lometrexol, a potent GARFT inhibitor, effectively blocks glycinamide ribonucleotide formyltransferase activity, thereby disrupting de novo purine synthesis. This inhibition leads to abnormal cell proliferation, apoptosis, and potential cell cycle arrest, demonstrating its anticancer properties. Additionally, Lometrexol acts as an inhibitor of human serine hydroxymethyltransferase 1 and 2 (hSHMT1/2), further influencing metabolic processes in cancer research applications.
Lometrexol, a potent GARFT inhibitor, effectively blocks glycinamide ribonucleotide formyltransferase activity, thereby disrupting de novo purine synthesis. This inhibition leads to abnormal cell proliferation, apoptosis, and potential cell cycle arrest, demonstrating its anticancer properties. Additionally, Lometrexol acts as an inhibitor of human serine hydroxymethyltransferase 1 and 2 (hSHMT1/2), further influencing metabolic processes in cancer research applications.
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