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- Julien Allard, .et al. Drug-induced Hepatic Steatosis in Absence of Severe Mitochondrial Dysfunction in HepaRG Cells: Proof of Multiple Mechanism-Based Toxicity, Cell Biol Toxicol, 2020, Jun 14 PMID: 32535746
Biological Activity
Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor.
Targets
| MTP | ||||
| In vitro | DMSO | 97 mg/mL (140.03 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 97 mg/mL (140.03 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.44 mL | 72.18 mL | 144.36 mL |
| 0.5 mM | 2.89 mL | 14.44 mL | 28.87 mL |
| 1 mM | 1.44 mL | 7.22 mL | 14.44 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.89 mL |
*The above data is based on the productmolecular weight 692.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12778 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 182431-12-5 |
| Formula | C39H37F6N3O2 |
| M. Wt | 692.71 |
| Purity | >98% |
| Synonyms | 0 |
| SMILES | C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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