Loratadine

Catalog No.: A10538

Loratadine Chemical Structure

CAS NO. 79794-75-5

Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Availability: In stock

Package Price Qty
10 mg
$45.00
25 mg
$80.00
50 mg
$120.00
100 mg
$190.00
10mM * 1mL in DMSO
$55.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Targets
H1 receptor B(0)AT2
N/A4 μM
In vitro DMSO 17 mg/mL (44.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 77 mg/mL (201.1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.15 mL 130.76 mL 261.51 mL
0.5 mM 5.23 mL 26.15 mL 52.3 mL
1 mM 2.62 mL 13.08 mL 26.15 mL
5 mM 0.52 mL 2.62 mL 5.23 mL

*The above data is based on the productmolecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10538
Actions N/A
M. Wt 382.39
Formula C22H23ClN2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 79794-75-5
Synonyms Alavert, Claritin
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

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