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Loratadine

Catalog No.: A10538
Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Loratadine
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Product Name Price Stock Qty
Loratadine 10mg
Special Price $36.00 Regular Price $45.00
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Loratadine 25mg
Special Price $64.00 Regular Price $80.00
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Loratadine 50mg
Special Price $96.00 Regular Price $120.00
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Loratadine 100mg
Special Price $152.00 Regular Price $190.00
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Loratadine 10mM * 1mL in DMSO
Special Price $44.00 Regular Price $55.00
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Biological Activity
Discription Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
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Target Value
Product Information
Catalog Num A10538
Formula C22H23ClN2O2
Molecular Weight 382.39
CAS Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Synonyms Alavert, Claritin
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro DMSO 15 mg/mL (39.18 mM)
Water Insoluble
Ethanol 68 mg/mL (177.6 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.15 mL 130.76 mL 261.51 mL
0.5 mM 5.23 mL 26.15 mL 52.3 mL
1 mM 2.62 mL 13.08 mL 26.15 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > Histamine Receptors
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