LSD1/EGFR-IN-1 is a potent inhibitor of lysine-specific demethylase 1 (LSD1) and several mutant forms of the epidermal growth factor receptor (EGFR), specifically EGFRT790M/L858R and EGFRL858R/T790M/C797S, exhibiting IC50 values of 6.24 μM, 2.06 μM, and 5.01 μM, respectively. This compound is significant for cancer research, particularly in studies focusing on targeted therapies and resistance mechanisms associated with EGFR mutations. Its application in preclinical models can aid in the understanding of tumorigenesis and the efficacy of combination therapies.
LSD1/EGFR-IN-1 is a potent inhibitor of lysine-specific demethylase 1 (LSD1) and several mutant forms of the epidermal growth factor receptor (EGFR), specifically EGFRT790M/L858R and EGFRL858R/T790M/C797S, exhibiting IC50 values of 6.24 μM, 2.06 μM, and 5.01 μM, respectively. This compound is significant for cancer research, particularly in studies focusing on targeted therapies and resistance mechanisms associated with EGFR mutations. Its application in preclinical models can aid in the understanding of tumorigenesis and the efficacy of combination therapies.
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