LSD1-IN-27 is a potent inhibitor of the lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 13 nM. This compound effectively inhibits the stemness and migratory capacity of gastric cancer cells while decreasing PD-L1 expression in BGC-823 and MFC cell lines. Additionally, LSD1-IN-27 has been shown to enhance T cell immune responses in the context of gastric cancer, making it a valuable tool for research in cancer immunotherapy and cellular differentiation studies.
LSD1-IN-27 is a potent inhibitor of the lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 13 nM. This compound effectively inhibits the stemness and migratory capacity of gastric cancer cells while decreasing PD-L1 expression in BGC-823 and MFC cell lines. Additionally, LSD1-IN-27 has been shown to enhance T cell immune responses in the context of gastric cancer, making it a valuable tool for research in cancer immunotherapy and cellular differentiation studies.
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