LSD1-IN-35 is a selective inhibitor of lysine-specific demethylase 1 (LSD1) with an IC50 of 108 nM. By inhibiting the demethylation of H3K4me1/2, LSD1-IN-35 acts as an immunomodulator, enhancing the response of gastric cancer cells to T-cell-mediated cytotoxicity. This compound decreases PD-L1 expression, thereby mitigating the PD-1/PD-L1 interaction, which is critical in tumor immune evasion. Its potential applications include cancer research and the study of immune regulation in tumor microenvironments.
LSD1-IN-35 is a selective inhibitor of lysine-specific demethylase 1 (LSD1) with an IC50 of 108 nM. By inhibiting the demethylation of H3K4me1/2, LSD1-IN-35 acts as an immunomodulator, enhancing the response of gastric cancer cells to T-cell-mediated cytotoxicity. This compound decreases PD-L1 expression, thereby mitigating the PD-1/PD-L1 interaction, which is critical in tumor immune evasion. Its potential applications include cancer research and the study of immune regulation in tumor microenvironments.
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