LSD1-IN-48 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), featuring a tranylcypromine-pyrimidine structure with a human IC50 of 7.87 nM. This compound enhances histone methylation levels of H3K4me1 and H3K4me2, promoting apoptosis in cancer cells. Additionally, LSD1-IN-48 upregulates CD86 and downregulates SOX2 and CD44, leading to reduced cell proliferation. It is particularly useful for research into acute myeloid leukemia.
LSD1-IN-48 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), featuring a tranylcypromine-pyrimidine structure with a human IC50 of 7.87 nM. This compound enhances histone methylation levels of H3K4me1 and H3K4me2, promoting apoptosis in cancer cells. Additionally, LSD1-IN-48 upregulates CD86 and downregulates SOX2 and CD44, leading to reduced cell proliferation. It is particularly useful for research into acute myeloid leukemia.
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