LSD1-UM-109 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 3.1 nM. It demonstrates significant antiproliferative activity, with IC50 values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line. This compound is valuable for research into cancer biology and the epigenetic regulation of gene expression, making it a crucial tool for studying LSD1’s role in various malignancies.
LSD1-UM-109 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), exhibiting an IC50 of 3.1 nM. It demonstrates significant antiproliferative activity, with IC50 values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line. This compound is valuable for research into cancer biology and the epigenetic regulation of gene expression, making it a crucial tool for studying LSD1’s role in various malignancies.
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