Lu AE98134 is a selective activator of voltage-gated sodium channel Nav1.1, functioning as a positive modulator. It also enhances the activity of Nav1.2 and Nav1.5 channels, while exhibiting no effect on Nav1.4, Nav1.6, or Nav1.7 channels. This compound serves as a valuable tool for investigating the pathophysiological roles of Nav1.1 in various central nervous system disorders, including potential applications in cognitive improvement in schizophrenia.
Lu AE98134 is a selective activator of voltage-gated sodium channel Nav1.1, functioning as a positive modulator. It also enhances the activity of Nav1.2 and Nav1.5 channels, while exhibiting no effect on Nav1.4, Nav1.6, or Nav1.7 channels. This compound serves as a valuable tool for investigating the pathophysiological roles of Nav1.1 in various central nervous system disorders, including potential applications in cognitive improvement in schizophrenia.
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