LXS196

Catalog No.: A19419

PKC inhibitor

LXS196

LXS196 Chemical Structure

CAS NO. 1874276-76-2

LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.

Availability: In stock

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2 mg

Regular Price: $70.00

Special Price $56.00

5 mg

Regular Price: $120.00

Special Price $96.00

10 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $600.00

Special Price $480.00

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Biological Activity

LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
In vitro DMSO 20 mg/mL (42.33 mM)
Water 5 mg/mL (10.58 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.17 mL 105.83 mL 211.65 mL
0.5 mM 4.23 mL 21.17 mL 42.33 mL
1 mM 2.12 mL 10.58 mL 21.17 mL
5 mM 0.42 mL 2.12 mL 4.23 mL

*The above data is based on the productmolecular weight 472.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19419
Actions Inhibitor
CAS No. 1874276-76-2
Formula C22H23F3N8O
M. Wt 472.47
Purity >98%
Synonyms LXS 196, LXS-196
SMILES NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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