LY2023-001 is a selective inhibitor of the G2019S mutation in LRRK2, exhibiting a potent inhibitory activity with an IC50 of 12.9 nM. This compound interacts with critical residues, forming stable hydrogen bonds with Glu1948 and Ala1950 in the G2019S LRRK2 protein. It serves as a valuable tool for investigating the role of LRRK2 signaling in neurodegenerative disorders, facilitating research in cellular models and drug development for Parkinson's disease.
LY2023-001 is a selective inhibitor of the G2019S mutation in LRRK2, exhibiting a potent inhibitory activity with an IC50 of 12.9 nM. This compound interacts with critical residues, forming stable hydrogen bonds with Glu1948 and Ala1950 in the G2019S LRRK2 protein. It serves as a valuable tool for investigating the role of LRRK2 signaling in neurodegenerative disorders, facilitating research in cellular models and drug development for Parkinson's disease.
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