LY2835219 methanesulfonate

Catalog No.: A16386

CDK4/6 inhibitor

LY2835219 methanesulfonate

LY2835219 methanesulfonate Chemical Structure

CAS NO. 1231930-82-7

LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$90.00
50 mg
$110.00
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Biological Activity

LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
In vitro (25°C) DMSO 81 mg/mL (134.39 mM)
Water 97 mg/mL (160.94 mM)
Ethanol 23 mg/mL
In vivo water 95 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.59 mL 82.96 mL 165.92 mL
0.5 mM 3.32 mL 16.59 mL 33.18 mL
1 mM 1.66 mL 8.3 mL 16.59 mL
5 mM 0.33 mL 1.66 mL 3.32 mL

*The above data is based on the productmolecular weight 602.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16386
Actions Inhibitor
CAS No. 1231930-82-7
Formula C27H32F2N8.CH4O3S
M. Wt 602.7
Solubility DMSO
Purity >98%
Synonyms Abemaciclib
SMILES CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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