LY2835219 methanesulfonate

LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
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LY2835219 methanesulfonate 5mg
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LY2835219 methanesulfonate 10mg
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LY2835219 methanesulfonate 50mg
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Adooq Products cited in reputable paper
Adooq's LY2835219 methanesulfonate has been cited by 1 publications
  • Shuso Takeda, .et al. , Fundam Toxicol Sci, 2021, 8(3):75-80
  • Biological Activity
    Discription LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
    Target Value
    Product Information
    Catalog Num A16386
    Formula C27H32F2N8.CH4O3S
    Molecular Weight 602.7
    CAS Number 1231930-82-7
    SMILES CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
    Synonyms Abemaciclib

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 81 mg/mL (134.39 mM)
    Water 97 mg/mL (160.94 mM)
    Ethanol 23 mg/mL
    In vivo water 95 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.59 mL 82.96 mL 165.92 mL
    0.5 mM 3.32 mL 16.59 mL 33.18 mL
    1 mM 1.66 mL 8.3 mL 16.59 mL
    5 mM 0.33 mL 1.66 mL 3.32 mL
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