LY3009120

Catalog No.: A16603

pan RAF inhibitor

LY3009120

LY3009120 Chemical Structure

CAS NO. 1454682-72-4

LY3009120 is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$78.00
50 mg
$230.00
100 mg
$460.00
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Biological Activity

LY3009120 is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively.
In vitro (25°C) DMSO Warmed: 3 mg/mL (7.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC Na 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.56 mL 117.78 mL 235.57 mL
0.5 mM 4.71 mL 23.56 mL 47.11 mL
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL

*The above data is based on the productmolecular weight 424.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16603
Actions Inhibitor
CAS No. 1454682-72-4
Formula C23H29FN6O
M. Wt 424.51
Purity >98%
Synonyms DP-4978
SMILES O=C(NC1=CC(C2=CC3=CN=C(NC)N=C3N=C2C)=C(C)C=C1F)NCCC(C)(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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