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LY315920 (Varespladib)

Catalog No.: A10548

HnsPLA inhibitor

LY315920 (Varespladib)

LY315920 (Varespladib) Chemical Structure

CAS NO. 172732-68-2

LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2).

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yap WH, .et al. Differential effects of sPLA2-GV and GX on cellular proliferation and lipid accumulation in HT29 colon cancer cells, Mol Cell Biochem, 2018, Oct;447(1-2):93-101 PMID: 29374817
  • Yamato Okita, .et al. Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes, Infect Immun, 2016, Feb; 84(2): 573-579 PMID: 26644377

Biological Activity

LY315920 (Varespladib) is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2).
7 nM
In vitro (25°C) DMSO 73 mg/mL (191.9 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.44 mL 262.88 mL
0.5 mM 5.26 mL 26.29 mL 52.58 mL
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10548
Actions Inhibitor
CAS No. 172732-68-2
Formula C21H20N2O5
M. Wt 380.4
Purity >98%
Synonyms LY-315920, S-5920

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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