LY3214996

Catalog No.: A16843

ERK inhibitor

LY3214996

LY3214996 Chemical Structure

CAS NO. 1951483-29-6

LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.

Availability: In stock

Package Price Qty
2 mg
$80.00
5 mg
$180.00
10 mg
$340.00
50 mg
$1,200.00
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Biological Activity

LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.
In vitro DMSO 24 mg/mL (52.91 mM)
Water Insoluble
Ethanol 14 mg/mL (30.86 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.24 mL 220.48 mL
0.5 mM 4.41 mL 22.05 mL 44.1 mL
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL

*The above data is based on the productmolecular weight 453.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16843
Actions Inhibitor
CAS No. 1951483-29-6
Formula C22H27N7O2S
M. Wt 453.56
Purity >98%
Synonyms LY 3214996, LY-3214996
SMILES CC(N(CCN1CCOCC1)C2=O)(C)C3=C2C=C(S3)C4=CC=NC(NC5=CC=NN5C)=N4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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